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These patent extension tricks certainly help to cushion the blow of the sales vacuum created by patent expirations, but they're no substitute for new products worth billions.Les Funtleyder, analyst for Miller Tabak, said that Big Pharma is paying the price for its "innovative black hole," and has "relatively few tools in the tool kit" to address the impending post patent sales dips."At some point, all big drugs are going to go off patent, and the question is: What does Big Pharma do next" said Funtleyder. "They could innovate their way out of the problem, or they could buy a pipeline, or they could go out of business."Pfizer's patent for Norvasc, the company's second biggest drug, expires in September. That marks the beginning of the end for a blood pressure drug that racked up nearly $5 billion in 2006 sales.

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