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sildenafil 20mg Traditional milk thistle extract is made from the seeds, which contain approximately 4 6% silymarin.[7] The extract consists of about 65 80% silymarin (a flavonolignan complex) and 20 35% fatty acids, including linoleic acid.[8] Silymarin is a complex mixture of polyphenolic molecules, including seven closely related flavonolignans (silybin A, silybin B, isosilybin A, isosilybin B, silychristin, isosilychristin, silydianin) and one flavonoid (taxifolin).[8] Silibinin, a semipurified fraction of silymarin, is primarily a mixture of 2 diastereoisomers, silybin A and silybin B, in a roughly 1:1 ratio.[8][9]Milk thistle has been used for a number of purposes including treatment of liver disease, prevention and treatment of cancer, and supportive treatment of poisoning from death cap mushrooms; however, clinical study results were described as heterogeneous and contradictory.[10] A 2007 Cochrane Review included eighteen randomized clinical trials which assessed milk thistle in 1088 patients with alcoholic and/or hepatitis B or C virus liver diseases. It questioned the beneficial effects and highlighted the lack of high quality evidence. The review concluded that more good quality, randomized clinical trials are needed.[11] Cancer Research UK say that milk thistle is promoted on the internet for its claimed ability to slow certain kinds of cancer, but that there is no good evidence in support of these claims.[12] Milk thistle may appear to stimulate prolactin due to possibly estrogenic activity.[13]Milk thistle based supplements have been measured to have the highest mycotoxin concentrations of up to 37 when compared amongst various plant based dietary supplements.[14] sildenafil 20mg.

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